Health

Advisory

EARLY REPORT OF SERIOUS EYE INFECTIONS

ASSOCIATED WITH SOFT CONTACT LENS SOLUTION

The Division of Public Health is forwarding this Health Advisory from the Centers for Disease Control and Prevention. To contact DPH

about this Health Advisory, call 1-888-295-5156. This number is answered during normal business hours, and during non-business hours for

emergencies.

This is an official

CDC Health Advisory

Distributed via Health Alert Network

May 25, 2007, 21:35 EDT (9:35 PM EDT)

CDCHAN-00260-07-05-25-ADV-N

Early Report of Serious Eye Infections

Associated with Soft Contact Lens Solution

The Centers for Disease Control and Prevention (CDC), collaborating with the Food and Drug Administration, state and other partners, has

identified an outbreak of a serious but rare eye infection called Acanthamoeba keratitis (AK). This infection is caused by a

free-living ameba (Acanthamoeba) a microscopic organism found everywhere in nature. Infections can result in permanent visual

impairment or blindness. AK primarily affects otherwise healthy people, most of whom wear contact lenses. In the United States, an

estimated 85% of cases of this infection occur in contact lens users. The incidence of the disease in the U.S. is approximately one to

two cases per million contact lens users.

CDC has received reports of 138 cases of culture-confirmed AK in 35 states and Puerto Rico, with complete patient data available for 46

case-patients. Thirty-nine of the 46 case-patients wore soft contact lenses. Preliminary information obtained by CDC from patient

interviews indicates that, among soft contact lens users who reported the use of any type of solution, 21 (58%) reported having used

Advanced Medical Optics (AMO) Complete^R MoisturePlus^TM Multi-Purpose Solution in the month prior to symptom onset.

Out of the 37 case-patients for whom clinical data was available, 9 (24%) failed medical therapy and required or are expected to undergo

corneal transplantation.

Based on these findings people who wear soft contact lenses who use Advanced Medical Optics (AMO) Complete^R

MoisturePlus^TMMulti-Purpose Solution should:

• Stop using the product immediately and discard all remaining solution including partially used or unopened bottles. Choose analternative contact lens solution.
• Discard current lens storage container.
• Discard current pair of soft lenses.
• See a health care provider if experiencing any signs of eye infection: Eye pain, eye redness, blurred vision, sensitivity to light,sensation of something in the eye, or excessive tearing.

All contact lens users should closely follow prevention measures to help prevent eye infections, which include

• See an eye care professional for regular eye examinations.
• Wear and replace contact lenses according to the schedule prescribed by an eye care professional.
• Remove contact lenses before any activity involving contact with water, including showering, using a hot tub, or swimming.
• Wash hands with soap and water and dry before handling contact lenses.
• Clean contact lenses according to the manufacturer’s guidelines and instructions from an eye care professional.
  • Use fresh cleaning or disinfecting solution each time lenses are cleaned and stored. Never reuse or top off old solution.
  • Never use saline solution and rewetting drops to disinfect lenses. Neither solution is an effective or approved disinfectant.
• Store reusable lenses in the proper storage case.
  • Storage cases should be rinsed with sterile contact lens solution (never use tap water) and left open to dry after each use.
  • Replace storage cases at least once every three months

Clinicians evaluating contact lens users with symptoms of eye pain or redness, tearing, decreased visual acuity, discharge, sensitivity

to light, or foreign body sensation should consider AK and refer the patient to an ophthalmologist, if appropriate. Diagnosis requires a

high degree of suspicion, especially in a contact lens wearer with a recent diagnosis of another form of keratitis, such as herpes

simplex virus keratitis, who is not responding to therapy.  Diagnosis is made on the basis of clinical picture and isolation of

organisms from corneal culture or detection of trophozoites and/or cysts on histopathology.  However, a negative culture does not

necessarily rule out Acanthamoeba infection. Confocal microscopy and polymerase chain reaction assays to detect

Acanthamoeba may also assist with diagnosis. Early diagnosis can greatly improve treatment efficacy.

Clinicians from Delaware have not reported any confirmed or suspect cases to CDC. Clinicians should consider obtaining clinical specimens

(e.g., corneal scrapings) for culture before initiating treatment. Clinicians or microbiology laboratories should report cases of AK to

Delaware Division of Public Health, Bureau of Epidemiology at 888-295-5156. Acanthamoeba isolates should be submitted to the

Delaware Public Health Laboratory (after consultation with Epidemiology) according to instructions provided by the Public Health

Laboratory

For more information, see the CDC website: http://www.cdc.gov/ncidod/dpd/parasites/acanthamoeba/index.htm