Health

Advisory

NATIONWIDE SHORTAGE OF DOXYCYCLINE: RESOURCES FOR PROVIDERS AND RECOMMENDATIONS FOR PATIENT CARE

FORWARDED FROM THE CDC BY THE DE DIVISION OF PUBLIC HEALTH

This is an official

CDC HEALTH ADVISORY

Nationwide Shortage of Doxycycline: Resources for Providers

and Recommendations for Patient Care

Summary

The Food and Drug Administration (FDA) originally reported a shortage of some forms of doxycycline (doxycycline hyclate) and

unavailability of tetracycline on January 18, 2013, caused by increased demand and manufacturing issues. FDA continues to report shortage

from some, but not all, manufacturers of some dosages and forms of doxycycline hyclate and doxycycline monohydrate. FDA does not

currently report a shortage of intravenous doxycycline hyclate or the oral suspension doxycycline calcium commonly used in pediatric

patients. For additional information about the availability of doxycycline, visit the FDA Drug Shortage website (http://www.fda.gov/Drugs/DrugSafety/DrugShortages/default.htm). Information about drug shortages can also be found at

the American Society of Health-System Pharmacists (ASHP) website (http://www.ashp.org/default.aspx). This notice provides advice on alternatives to doxycycline when available, as well

as situations where there is no recommended alternative to doxycycline.

Background

Doxycycline is a broad-spectrum, bacteriostatic antibiotic used to treat a variety of diseases. For many indications, doxycycline is one

of several options available for patients. However, for rickettsial infections, doxycycline is the treatment of choice. No data are

available to recommend minocycline as an equally effective alternative to doxycycline for any of the diseases mentioned. Additionally,

the spectrum of adverse effects with minocycline is higher than that for doxycycline. Tetracycline may be a suitable alternative for some

diseases and indications; however, a similar shortage of tetracycline has been reported.

Recommendations

1. Doxycycline should be used to treat suspected rickettsial infections; no alternatives can be recommended that have the same provendegree of efficacy in limiting fatal outcome. Because treatment delay can result in adverse or fatal outcome, planning for doxycycline

   availability is essential.

2. Doxycycline is the recommended drug for prophylaxis of Lyme disease; alternatives have not been tested for efficacy. Providers shouldbe judicious in its use following a tick bite.
3. Doxycycline should still be used for the prophylaxis and treatment of malaria according to the standard recommendations.
4. Alternatives exist for the treatment of STDs and Lyme disease. Providers should use clinical judgment in making treatment andprophylactic decisions. Refer to the links in the section below.

Detailed explanation of the rationale for these recommendations can be found in the Detailed Disease Treatment

Information section below. Doxycycline is currently available from most manufacturers, although providers may need to explore

new contracts for procurement; projected return to availability for the one manufacturer reporting a shortage is uncertain, but is

currently projected by September 2013, based on information provided by FDA. Health care professionals should ensure they have access to

doxycycline for the listed indications, and advance planning is essential to ensure treatment is not delayed. Those who encounter

difficulty ordering doxycycline or increased pricing from their usual suppliers should contact alternate distributors or directly contact

the manufacturers. In circumstances where outages and increased pricing occur, health-care professionals should contact their state

health department to inquire about other procurement options. For additional information about the availability of doxycycline, visit the

FDA Drug Shortage website (http://www.fda.gov/Drugs/DrugSafety/DrugShortages/default.htm). Information about drug shortages can also be

found at the American Society of Health-System Pharmacists (ASHP) website (http://www.ashp.org/default.aspx).

Detailed Disease Treatment Information

Rickettsial Infections

Despite the shortage, doxycycline continues to be the recommended therapy for the treatment of suspected rickettsial infections

(including Rocky Mountain spotted fever, ehrlichiosis, and anaplasmosis) in patients of all ages, including children younger than 8

years. Rapid, empiric treatment with doxycycline is essential to prevent severe morbidity and mortality, and delay in treatment while

waiting for test results or evidence of a worsening condition is highly contraindicated. While chloramphenicol is sometimes suggested as

a possible treatment alternative, its use to treat rickettsial infections is associated with a significantly higher risk of fatal outcome

and is not recommended unless there are specific life-threatening contraindications for doxycycline use (1). Other

broad-spectrum antibiotics, including fluoroquinolones, are ineffective in treating rickettsial infections. For more information on

treating rickettsial infections, refer to Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever,

Ehrlichiosis and Anaplasmosis – United States (http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5504a1.htm).

Lyme Disease

Doxycycline is one of several possible antibiotics used in the treatment of Lyme disease. Alternative antibiotics commonly used for oral

treatment of Lyme disease are amoxicillin and cefuroxime axetil. For detailed recommendations on treatment, consult the 2006 guidelines

for treatment developed by the Infectious Diseases Society of America (IDSA) (http://cid.oxfordjournals.org/content/43/9/1089.full).

The efficacy of drugs other than doxycycline for Lyme disease prophylaxis following a tick bite has not been tested. Single-dose

amoxicillin is not recommended for Lyme disease prophylaxis because of its short half-life. For more information on prophylaxis of Lyme

disease, see the 2006 IDSA guidelines (http://cid.oxfordjournals.org/content/43/9/1089.full).

Malaria

Doxycycline is one of several possible medicines used for both the prevention and treatment of malaria. For information about choosing

the best drug to prevent malaria for a particular traveler to a malaria endemic country or for treating a patient with malaria, please

see the CDC malaria website (http://www.cdc.gov/malaria).

Sexually Transmitted Diseases

Doxycycline is a recommended therapy for some sexually transmitted infections and syndromes including chlamydia, nongonococcal

urethritis, epididymitis, and pelvic inflammatory disease. It is also an alternative therapy for syphilis in patients with a penicillin

allergy. Alternative regimens using other antibiotics to treat these infections are described in the 2010 STD Treatment

Guidelines (http://www.cdc.gov/std/treatment/2010/default.htm). For additional recommendations, please contact a specialist or

local health department.

References

1. Holman RC, Paddock CD, Curns AT, Krebs JW, McQuiston JH, Childs JE. Analysis of risk factors for fatal Rocky Mountain spotted fever:

evidence for superiority of tetracyclines for therapy. J Infect Dis. 2001 Dec 1; 184(11):1437-44.

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